Anal cancer recurrence

Comprehensive image features were extracted from CT and PET SUV images within manually delineated gross tumor volume, including geometry features, intensity features and texture features. The difference of feature values between two time points were also computed and analyzed. The area under the receiver operating characteristic ROC curve AUC was used to evaluate the accuracy of the prediction. In univariate analysis, six geometry, three intensity, and six texture features were identified as significant predictors of tumor recurrence. Anal cancer is a relatively uncommon malignancy. In the United States, the National Cancer Institute estimated 8, new cases and 1, deaths from anal cancer in 1.
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Living as an Anal Cancer Survivor

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Anal Cancer Treatment (PDQ®)–Patient Version - National Cancer Institute

Kaplan-Meier overall survival for patients who received chemoradiotherapy and for patients who underwent surgical excision. Patterns of Recurrence in Anal Canal Carcinoma. Arch Surg. Anal margin cancers and adenocarcinomas were excluded. Therefore, chemoradiotherapy is justified as the initial treatment for ACC and has an overall 5-year survival that is significantly higher than that attained with initial surgical treatment.
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Patterns of recurrence in anal cancer: a detailed analysis

Due to the low incidence of anal cancer and generally high cure rates, few second-line treatment options have been evaluated in the setting of formal clinical trials. We briefly report two cases that were both found to have wild-type K-RAS, with no epidermal growth factor receptor amplification or evidence of prior persistent human papilloma virus infection. Both cases were treated with irinotecan and cetuximab with evidence of clinical benefit in the setting of a third recurrence, as well as evidence of response to other strategies employed in their management. These cases provide support for the suggestion that treatment planning in conjunction with molecular profiling may be beneficial in such uncommon clinical settings.
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Anal cancer is a rare malignancy with approximately 5, new cases diagnosed annually in the United States. As a result of carefully conducted epidemiologic and clinical studies, it is now established that anal cancer is closely associated with human papillomavirus HPV infection. The cure of anal cancer is possible in the majority of patients with preservation of the anal sphincter. This malignancy has been historically treated by abdominoperineal resection, with associated high rates of morbidity and local recurrence.
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