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Since DHT is applied daily, avoiding all direct contact to the genitals throughout the period of usage is recommended. Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. All patients demonstrated growth of the penis during treatment. A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency We conclude that 3 months treatment with transdermal dihydrotestosterone gel demonstrates expected androgenic effects, short-term safety, and limited improvement in lower limb muscle strength but no change in physical functioning or cognitive function. Long-term transdermal dihydrotestosterone therapy: effects on pituitary gonadal axis and plasma lipoproteins.